19 March, 2010
Volume 140, Issue 6

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Volume 140, Issue 6

On the cover: Inflammation is a multifaceted and varied immune response that is a critical protagonist in the fight against infection. Yet its dark side is equally potent. In autoimmune disease, inflammation wreaks havoc on self tissues and, when chronically activated, fans the flames of cancer. The cover image illustrates the interconnection between inflammation and diverse physiological processes by linking together the Latin terms for inflammation's main clinical symptoms—tumor (swelling), calor (heat), rubor (redness), and dolor (pain)—first recorded by Aulus Cornelius Celsus in the ancient Roman medical text De medicina. In the present day, our increasingly sophisticated appreciation of the cellular processes and molecular mediators that give rise to inflammation affords unprecedented opportunities for the treatment of human disease.

Announcements

  • Cell Welcomes New Members to the Editorial Board
    Stephen Cohen, Ted Dawson, Narry Kim, Mary-Claire King, Robert Lamb, Craig Mello, Kathrin Plath, Trina Schroer, and Shinya Yamanaka
  • Article of the Future Is Here!
    Cell Press launches a new article format online.
    » Learn more
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Cell 2009
Year in Review

  • A comprehensive collection of the important biological questions of the year, this bound, hardcover edition includes all 37 reviews published in Cell in 2009. Learn more.

Recent Comments

  • Ignacio Alastuey Gonzalez commented, "I find the article most thought provoking because this process of tumor self seeding might explain..." | Read the article.
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Announcing the Inaugural Cell Symposia

Inflammation & Disease
» September 26–28, 2010 | Lisbon, Portugal
» Abstract submission deadline: May 17, 2010
» Register Now! | Submit your abstract.

Influenza
» December 2–4, 2010 | Washington, DC
» Abstract submission deadline: July 2, 2010
» Register Now! | Submit your abstract.



SnapShot

Latest SnapShot

SnapShots present up-to-date tables of nomenclature and glossaries, full signaling pathways, and schematic diagrams of cellular processes. Click here for the full list of SnapShots.

Reactive Oxygen Intermediates (ROI)
Carl Nathan and Aihao Ding

Cell Career Network

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Email: ads@cell.com

Job Seekers: View the latest Jobs in Cancer and Oncology on the all-new Cell Career Network!

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Message from Emilie Marcus, Editor-in-Chief

Cell Launches a New Format for the Presentation of Research Articles Online

"In collaboration with our authors and readers, we have developed an online format that breaks free from the restraints of paper and allows each reader to create a personalized path through the article’s content . . . "

Learn more about the "Article of the Future" initiative.

View an article in the new format.

Tell us what you think!


SPECIAL REVIEW ISSUE 2010: INFLAMMATION


Essay and Review Highlights

Highlight 1 Taming Allergy
In this Essay, Richard Locksley dissects allergic inflammation and the underlying misregulated interactions between mucosal epithelia and innate immune cells.

Highlight 2 The Ying-Yang of Inflammation Regulation
In this Review, Dan Littman and Alexander Rudensky discuss how organisms strike the balance between driving inflammation (the remit of Th17 cells) and reigning in the inflammatory response (the remit of Treg cells).

Highlight 2 Selecting the Correct Response
In this Review, Stephen Smale discusses our current understanding of how chromatin and transcription factors regulate the expression of proinflammatory genes.

For a complete table of contents, click here.


Immediate Early Publication

Second Messenger-Mediated Adjustment of Bacterial Swimming Velocity
Alex Boehm, Matthias Kaiser, Hui Li, Christian Spangler, Christoph Alexander Kasper, Martin Ackermann, Volkhard Kaever, Victor Sourjik, Volker Roth, and Urs Jenal

Molecular and Cellular Approaches for Diversifying and Extending Optogenetics
Viviana Gradinaru, Feng Zhang, Charu Ramakrishnan, Joanna Mattis, Rohit Prakash, Ilka Diester, Inbal Goshen, Kimberly R. Thompson, and Karl Deisseroth


Featured Essay  free

Featured Article Inflammation Illuminated
In this Overview Essay, Ruslan Medzhitov explores the inflammatory response from the perspectives of the frontline defense against injury and infection and a major mediator of tissue homeostasis.

Inflammation 2010: New Adventures of an Old Flame
Ruslan Medzhitov


Featured Review  free

Leading Edge Featured Article When inflammation Runs Amok
In this Review, Carl Nathan and Aihao Ding discuss the ramifications of an inflammatory response that cannot be switched off and the diseases associated with the failure to resolve inflammation.

Nonresolving Inflammation
Carl Nathan and Aihao Ding


Special Issue Podcast

Special Issue Podcast In this Special Issue podcast, scientific editor Fabiola Rivas introduces the 2010 Cell Special Review Issue on Inflammation with interviews by Ruslan Medzhitov and Jurg Tschopp.


Image courtesy of Lorenzo Galluzzi and Oliver Kepp.

You can listen directly by clicking on the player above. For a complete list of Cell Press podcasts, view the archive.

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Cell Podcast

Podcast In our February podcast, we hear from Colin Renfrew about the earliest journeys of our ancestors revealed by archaeogenetics (0:50). Next, we learn from Bob Roeder about a versatile transcription elongation factor with several key functions in the cell (11:12). And stay tuned for a conversation with Mike Cleary about an oncoprotein and its many partners, which are involved in leukemia (16:21).

You can listen directly by clicking on the player above. For a complete list of Cell Press podcasts, view the archive.

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Cell PaperClips

Dr. Simon Prochnik In this PaperClip, Bob Kruger speaks with Simon Prochnik about the surprising genome complexity of the free-living single-cell organism Naegleria gruberi.

You can listen directly by clicking on the player above. For a complete list of Cell PaperClips, view the archive.

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