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Copyright © 2008 The American Society of Human Genetics. All rights reserved.
The American Journal of Human Genetics, Volume 82, Issue 5, 1193-1201, 24 April 2008

doi:10.1016/j.ajhg.2008.03.017

Report

Polymorphisms of the HNF1A Gene Encoding Hepatocyte Nuclear Factor-1α are Associated with C-Reactive Protein

Alexander P. Reiner^1, ,  , Mathew J. Barber², Yongtao Guan², Paul M. Ridker³, Leslie A. Lange⁴, Daniel I. Chasman³, Jeremy D. Walston⁵, Gregory M. Cooper⁶, Nancy S. Jenny⁷, Mark J. Rieder⁶, J. Peter Durda⁷, Joshua D. Smith⁶, John Novembre², Russell P. Tracy⁷, Jerome I. Rotter⁸, Matthew Stephens², Deborah A. Nickerson⁶ and Ronald M. Krauss⁹

¹ University of Washington, Department of Epidemiology, Seattle, WA 98195, USA
² University of Chicago, Department of Statistics, Chicago, IL 60637, USA
³ Center for Cardiovascular Disease Prevention, Brigham and Women's Hospital, Boston, MA 02215, USA
⁴ Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA
⁵ Department of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
⁶ University of Washington Department of Genome Sciences, Seattle, WA 98195, USA
⁷ Department of Pathology, University of Vermont College of Medicine, Burlington, VT 05446, USA
⁸ Medical Genetics Institute, Cedars-Sinai Medical Center West Los Angeles, CA 90048-1804, USA
⁹ Children's Hospital Oakland Research Institute, Oakland, CA 94609, USA

Corresponding author

Abstract

Data from the Pharmacogenomics and Risk of Cardiovascular Disease (PARC) study and the Cardiovascular Health Study (CHS) provide independent and confirmatory evidence for association between common polymorphisms of the HNF1A gene encoding hepatocyte nuclear factor-1α and plasma C-reactive protein (CRP) concentration. Analyses with the use of imputation-based methods to combine genotype data from both studies and to test untyped SNPs from the HapMap database identified several SNPs within a 5 kb region of HNF1A intron 1 with the strongest evidence of association with CRP phenotype.

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